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When Bcl-2 was overexpressed, it heterodimerized with Bax and Loss of life was repressed, As a result the ratio of Bcl-two to Bax is important in figuring out susceptibility to apoptosis [42]. On this research, our effects revealed that Bcl-2 expression was down-controlled remarkably though Bax expression along with the Energetic method of caspase-